|
KMID : 1123920070210030700
|
|
Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 3 p.700 ~ p.704
|
|
|
Composition Comprising the Extract of Anethi Fructus for the Treatment and Protection of Immune Activity
|
|
Kim Youn-Chul
Choi Du-Young
Yun Young-Gab
Park Hyun
|
|
|
Abstract
|
|
|
|
In the recent, increased concern has been focused on the pharmacology and clinical utility of herbal extracts and derivatives as a drug or adjunct to chemotherapy and immunotherapy. Here we investigated the role of the extract of Anethi Fructus in the expression of inflammatory mediators, surface molecule, and related receptors in vitro. In murine macrophage RAW 264.7 cells and peritoneal macrophages of C57BL/6N mice, water extract of Anethi Fructus increased the production of secretary tumor necrosis factor (TNF)-a and Nitric oxide (NO), and the expression level of CD14, LPS co-receptor and CD86, co-stimulatory molecule compared to negative natural extract ex vivo. The water extract of Anethi Fructus increased the production of interferon (IFN)-g from splenocytes. Also, water extract of Anethi Fructus increased ConA-induced cell proliferation. These results suggest that water extract of Anethi Fructus may enhance the immune response through immune modulation of macrophage and lymphocytes.
|
|
|
KEYWORD
|
|
|
Anethi Fructus, TNF-a, Nitric oxide, co-stimulatory molecule
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|